The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2022

Filed:

Jul. 03, 2019
Applicants:

Cathay Biotech Inc., Shanghai, CN;

Cibt America Inc., Newark, DE (US);

Inventors:

Wenbo Liu, Shanghai, CN;

Min Xu, Shanghai, CN;

Chen Yang, Shanghai, CN;

Howard Chou, Shanghai, CN;

Xiucai Liu, Shanghai, CN;

Assignees:

CATHAY BIOTECH INC., Shanghai, CN;

CIBT AMERICA INC., Newark, DE (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 7/44 (2006.01); C12N 15/52 (2006.01); C12N 9/02 (2006.01); C12N 15/01 (2006.01); C12P 7/6409 (2022.01);
U.S. Cl.
CPC ...
C12P 7/44 (2013.01); C12N 15/52 (2013.01); C12Y 103/03006 (2013.01);
Abstract

The present invention relates to a long-chain dibasic acid with low content of long-chain dibasic acid impurity of shorter carbon chain, to the preparation of a long-chain dibasic acid producing strain by directed evolution of POX gene and homologous recombination, and to the production of a long-chain dibasic acid with low content of long-chain dibasic acid impurity of shorter carbon chain by using the strain. The present invention also relates to a strain containing a mutated promoter, wherein, when a long-chain dibasic acid is produced by fermentation of this strain, the content of the acid impurity of shorter carbon chain in the fermentation product is significantly reduced.


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