The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
May. 26, 2020
The Scripps Research Institute, La Jolla, CA (US);
R. Luke Wiseman, Chula Vista, CA (US);
Jeffery W. Kelly, La Jolla, CA (US);
Julia M. D. Grandjean, San Diego, CA (US);
Christina B. Cooley, San Antonio, TX (US);
Lars Plate, Nashville, TN (US);
Enrique Saez, San Diego, CA (US);
Aparajita Madhavan, San Diego, CA (US);
Bernard Kok, La Jolla, CA (US);
The Scripps Research Institute, La Jolla, GA (US);
Abstract
Disclosed herein are compounds, their pharmaceutical salts, and pharmaceutical compositions that selectively activate the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1s) signaling pathway of the unfolded protein response (UPR), but that do not target the IRE1 kinase domain. The compounds are useful in treating diseases or conditions characterized by imbalances in proteostasis within the endoplasmic reticulum (ER) or secretory pathway, including those not associated with ER stress or activation of UPR.