The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 16, 2022

Filed:

Jun. 30, 2017
Applicants:

Riken, Saitama, JP;

Japanese Foundation for Cancer Research, Tokyo, JP;

Kabushiki Kaisha Yakult Honsha, Tokyo, JP;

Inventors:

Minoru Yoshida, Wako, JP;

Hiroyuki Seimiya, Tokyo, JP;

Masayuki Okue, Yokohama, JP;

Yoko Yashiroda, Wako, JP;

Fumiyuki Shirai, Wako, JP;

Takeshi Tsumura, Yokohama, JP;

Yuko Kano, Yokohama, JP;

Kenichi Washizuka, Wako, JP;

Nobuko Yoshimoto, Wako, JP;

Yasuko Kouda, Wako, JP;

Takehiro Fukami, Wako, JP;

Tsubasa Chikada, Yokohama, JP;

Takashi Watanabe, Yokohama, JP;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/20 (2006.01); C07D 519/00 (2006.01); C07D 471/10 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); C07D 471/10 (2013.01); C07D 471/20 (2013.01); C07D 491/107 (2013.01);
Abstract

Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.5]undeca-1-ene structure represented by the following general formula (1):


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