The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Dec. 06, 2018
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Wilson Wolf Manufacturing Corporation, New Brighton, MN (US);
Steven A. Rosenberg, Potomac, MD (US);
Mark E. Dudley, Washington, DC (US);
David Stroncek, Rockville, MD (US);
Marianna Sabatino, Los Angeles, CA (US);
Jianjian Jin, Clarksburg, MD (US);
Robert Somerville, Potomac, MD (US);
John R. Wilson, New Brighton, MN (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Wilson Wolf Manufacturing Corporation, New Brighton, MN (US);
Abstract
An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.