The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Jun. 24, 2016
Keio University, Tokyo, JP;
National University Corporation Kochi University, Kochi, JP;
Tomonori Yaguchi, Tokyo, JP;
Kenji Morii, Tokyo, JP;
Yutaka Kawakami, Tokyo, JP;
Daiki Kato, Tokyo, JP;
Tetsuji Naka, Ibaraki, JP;
Satoshi Serada, Ibaraki, JP;
Minoru Fujimoto, Ibaraki, JP;
Keio University, Tokyo, JP;
NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY, Kochi, JP;
Abstract
The purpose of the present invention is to produce a chimeric antigen receptor (CAR) specific to glypican-1 (GPC-1) and to treat squamous cell carcinoma with genetically modified cells capable of expressing the CAR. The present invention provides: a chimeric antigen receptor for use in the treatment and/or prevention of squamous cell carcinoma, said chimeric antigen receptor comprising an extracellular domain capable of binding to GPC-1, a transmembrane domain and one or multiple intracellular domains, wherein at least one of the intracellular domains is an intracellular domain containing a primary cytosolic signaling sequence or an intracellular domain containing both a primary cytosolic signaling sequence and a secondary cytosolic signaling sequence; a genetically modified cell capable of expressing the chimeric antigen receptor; and a cell preparation containing the cell.