The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Dec. 22, 2017
Universite DE Montpellier, Montpellier, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Centre Hospitalier Universitaire DE Montpellier, Montpellier, FR;
Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;
Ecole Nationale Superieure DE Chimie DE Montpellier—enscm, Montpellier, FR;
Guillaume Laconde, Montpellier, FR;
Muriel Amblard-Caussil, Saint Vincent de Barbeyrargues, FR;
Jean Martinez, Caux, FR;
Christian Jorgensen, Lattes, FR;
Florence Apparailly-Sechan, Montpellier, FR;
Isabelle Duroux-Richard, Vailhauques, FR;
Universite de Montpellier, Montpellier, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Abstract
The present invention relates to peptidomimetic macrocycles comprising at least one macrocycle-forming linker and an amino acid sequence chosen from the group consisting of: i) an amino acid sequence with at least about 50%, 60%, 70%, 80%, 90%, or 95% sequence identity to a human sequence IRAK2 54-71 (SEQ ID No1) and 100% identity with the amino acids in the positions 5-6, 9-11, 14-15 or ii) an amino acid sequence with at least about 50%, 60%, 70, 80%, 90%, or 95% sequence identity to a human sequence IRAKM 66-83 (SEQ ID No2) and 100% identity with the amino acids in the positions 5-6, 9-11, 13-14, wherein the peptidomimetic macrocycle comprises an a-helix and at least two natural or two non-natural amino acids crosslinked by a macrocycle-forming linker. It also concerns method of preparation of said peptidomimetic macrocycles and uses thereof, pharmaceutical composition and uses thereof, in particular as inhibitors of inflammatory pathways.