logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11332717 B1

PDFFull Text
Date of Patent:
May. 17, 2022

Filed:

Jul. 21, 2016

Three-dimensional vascular network assembly from induced pluripotent stem cells

Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Sharon Gerecht, Severna Park, MD (US);

Xin Yi Chan, Baltimore, MD (US);

Quinton Smith, Albuquerque, NM (US);

Yu-I Shen, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:

Venable LLP

Keith G. Haddaway

Primary Examiner:

Thaian N Ton

Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 47/36 (2006.01); A61K 47/42 (2017.01); A61K 35/00 (2006.01); A61K 35/545 (2015.01); A61P 31/02 (2006.01); A61L 27/24 (2006.01);
U.S. Cl.
CPC ...
C12N 5/069 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 35/00 (2013.01); A61K 35/545 (2013.01); A61K 47/36 (2013.01); A61K 47/42 (2013.01); A61L 27/24 (2013.01); A61P 31/02 (2018.01); C12N 2500/44 (2013.01); C12N 2501/165 (2013.01); C12N 2501/727 (2013.01); C12N 2501/999 (2013.01); C12N 2506/45 (2013.01); C12N 2533/80 (2013.01);
Abstract

Early vascular cells (EVCs), including endothelial cells and pericytes, are generated from hiPSCs. Unlike the isolated endothelial progenitor cells, the differentiated ECs mature and are functional. When encapsulated in synthetic hydrogel, EVCs respond to matrix cues and self-assembled to form three-dimensional EVCs. Moreover, these EVCs respond to hypoxic microenvironment and undergo vasculogenesis to form complex 3D networks.

Find Patent Forward Citations

Gerecht, Sharon. (2022). Three-dimensional vascular network assembly from induced pluripotent stem cells (U.S. Patent No. 11332717). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11332717

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…