The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2022

Filed:

May. 04, 2020
Applicant:

Stratos Genomics, Inc., Seattle, WA (US);

Inventors:

Mark Stamatios Kokoris, Bothell, WA (US);

Marc Prindle, Seattle, WA (US);

Melud Nabavi, Seattle, WA (US);

Craig Ostrander, Bothell, WA (US);

Taylor Lehmann, Seattle, WA (US);

Samantha Vellucci, Seattle, WA (US);

Michael Kovarik, Seattle, WA (US);

Jack Chase, Seattle, WA (US);

Robert Busam, Seattle, WA (US);

Miranda Lahman, Seattle, WA (US);

Assignee:

Stratos Genomics, Inc., Seattle, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12N 15/10 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/10 (2013.01); C07H 21/04 (2013.01); C12N 9/1252 (2013.01); C12Y 207/07007 (2013.01);
Abstract

Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.


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