The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2022

Filed:

Sep. 15, 2017
Applicant:

Research Triangle Institute, Research Triangle Park, NC (US);

Inventors:

Frank Ivy Carroll, Research Triangle Park, NC (US);

Chad M. Kormos, Research Triangle Park, NC (US);

Pauline W. Ondachi, Research Triangle Park, NC (US);

Scott P. Runyon, Research Triangle Park, NC (US);

Hernan A. Navarro, Research Triangle Park, NC (US);

James B. Thomas, Research Triangle Park, NC (US);

S. Wayne Mascarella, Research Triangle Park, NC (US);

Assignee:

Research Triangle Institute, Research Triangle Park, NC;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/472 (2006.01); C07D 217/26 (2006.01); C07D 401/12 (2006.01); A61P 25/34 (2006.01); A61P 25/36 (2006.01); A61P 25/32 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); C07D 211/18 (2006.01); C07D 413/12 (2006.01); C07D 487/08 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 25/00 (2018.01); A61P 25/18 (2018.01); A61P 25/24 (2018.01); A61P 25/32 (2018.01); A61P 25/34 (2018.01); A61P 25/36 (2018.01); C07D 211/18 (2013.01); C07D 217/26 (2013.01); C07D 413/12 (2013.01); C07D 487/08 (2013.01);
Abstract

Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.


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