The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Apr. 14, 2017
Berkeley Lights, Inc., Emeryville, CA (US);
Kevin T Chapman, Emeryville, CA (US);
Xiaohua Wang, Pomona, NY (US);
Xiao Guan Radstrom, San Rafael, CA (US);
Yelena Bronevetsky, Alameda, CA (US);
Guido K Stadler, San Francisco, CA (US);
Gregory G Lavieu, Vitry sur Seine, FR;
Annamaria Mocciaro, San Francisco, CA (US);
Berkeley Lights, Inc., Emeryville, CA (US);
Abstract
The present disclosure provides methods of preparing tumor infiltrating cells engineered to express a pro-inflammatory polypeptide. The pro-inflammatory polypeptide is expressed from the tumor infiltrating cell to counter a generally immunosuppressive state in and around tumors resulting from an imbalance between the number and activation state of immune effector cells versus those of suppressor cells. Delivering the proinflammatory polypeptide via expression from the TICs, as distinct from systemic administration, reduces side effects from increased inflammation at sides remote from a tumor to be treated.