The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Oct. 02, 2018
Applicant:
Academia Sinica, Taipei, TW;
Inventors:
Chi-Huey Wong, La Jolla, CA (US);
Chung-Yi Wu, Taipei, TW;
Assignee:
ACADEMIA SINICA, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C12P 21/005 (2013.01); C12Y 204/01038 (2013.01); C12Y 204/99 (2013.01); C12Y 302/01051 (2013.01); C07K 2317/10 (2013.01); C07K 2317/21 (2013.01); C07K 2317/41 (2013.01);
Abstract
Modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided.