The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2022

Filed:

Sep. 29, 2017
Applicant:

National University Corporation Tokyo Medical and Dental University, Tokyo, JP;

Inventors:

Takanori Yokota, Tokyo, JP;

Kotaro Yoshioka, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 9/00 (2006.01); A61P 25/28 (2006.01); A61K 31/7125 (2006.01); A61P 35/00 (2006.01); A61K 9/70 (2006.01); C12N 15/09 (2006.01); C12N 15/113 (2010.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 9/0019 (2013.01); A61K 9/7023 (2013.01); A61K 31/7088 (2013.01); A61K 31/7125 (2013.01); A61K 48/00 (2013.01); A61P 25/28 (2018.01); A61P 35/00 (2018.01); C12N 15/09 (2013.01); C12N 15/113 (2013.01);
Abstract

Provided is a nucleic acid strand that can efficiently deliver an antisense oligonucleotide into the body, particularly a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein the first nucleic acid strand includes a base sequence that is capable of hybridizing with at least a portion of a target transcription product, and exerts an antisense effect on the target transcription product; the second nucleic acid strand includes a complementary region having a base sequence complementary to the first nucleic acid strand and at least one overhang region located on the 5' and/or 3′ side of the complementary region; and the first nucleic acid strand is annealed to the complementary region in the second nucleic acid strand.


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