The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2022
Filed:
Jun. 09, 2021
Applicant:
The Usa, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Joel Morris, Rockville, MD (US);
Donn G. Wishka, Middletown, MD (US);
Omar Diego Lopez, Walkersville, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 409/04 (2006.01);
U.S. Cl.
CPC ...
C07D 409/04 (2013.01);
Abstract
Halogenated analogs of 5-aza-2'-deoxycytidine, such as halogenated analogs of 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated analogs to inhibit neoplasia are described. In some examples, the halogenated analogs have a structure according to formula Ia, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: