The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2022
Filed:
Oct. 02, 2018
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Frank Rigo, Carlsbad, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Adrian R. Krainer, Huntington Station, NY (US);
Zhenxun Wang, Singapore, SG;
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Abstract
The present invention provides compounds comprising oligonucleotides complementary to a pyruvate kinase M transcript. Certain such compounds are useful for hybridizing to a pyruvate kinase M transcript, including but not limited to a pyruvate kinase M transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the pyruvate kinase M transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with cancer.