The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Mar. 05, 2018
California Institute of Technology, Pasadena, CA (US);
David Reza Mittelstein, Pasadena, CA (US);
Morteza Gharib, Pasadena, CA (US);
Stefanie Heyden, Pasadena, CA (US);
Michael Ortiz, Pasadena, CA (US);
Mikhail G. Shapiro, Pasadena, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at a resonance frequency ('oncotripsy') for the specific cell types are presented. The systems and the methods result in permeabilization, lysis, and/or death of the targeted specific cell types by using ultrasonic harmonic excitations that have a frequency and a pulse duration specifically tuned to disrupt nuclear membranes of the targeted specific cell types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.