The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 18, 2022
Filed:
Jan. 25, 2018
Applicant:
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Inventors:
Jianjun Cheng, Champaign, IL (US);
Lin-Feng Chen, Champaign, IL (US);
Menghua Xiong, Guangzhou, CN;
Yan Bao, Guangzhou, CN;
Assignee:
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 38/00 (2006.01); C07K 1/107 (2006.01);
U.S. Cl.
CPC ...
C07K 14/001 (2013.01); A61K 38/00 (2013.01); C07K 1/1072 (2013.01);
Abstract
The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g.,) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.