The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 18, 2022
Filed:
Aug. 23, 2021
Catalent U.k. Swindon Zydis Limited, Swindon, GB;
Mymetics Corporation, Epalinges, CH;
Yik Teng Wong, Wiltshire, GB;
Charli Smardon, Wiltshire, GB;
Khojasteh Shirkhani, Swindon, GB;
Mario Amacker, Schmitten, CH;
Sylvain Fleury, Bottens, CH;
Antonius Johannes Hendrikus Stegmann, Rijnsburg, NL;
Catalent U.K. Swindon Zydis Limited, Wiltshire, GB;
Mymetics Corporation, Epalinges, CH;
Abstract
The present disclosure is directed to oral vaccine dosage forms and processes for producing the oral vaccine dosage forms. The dosage forms include lipid-based vesicles (e.g., virosomes, liposomes) harboring an immunogenic amount of at least one vaccinal target molecule, with or without adjuvant. Specifically, Applicants discovered a combination of the composition of the liquid virosome concentrates, the composition of the base matrix for the solid dosage form formulation (excluding the virosome concentrate), and the manufacturing conditions for the dosage forms that can produce a freeze dried sublingual dosage form having physical robustness, particle and antigen integrity and stability.