The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2021
Filed:
May. 04, 2021
Genus Plc, DeForest, WI (US);
Andrew Mark Cigan, Madison, WI (US);
Jonathan Edward Lightner, Jefferson, WI (US);
Matthew Scott Culbertson, Wilmington, NC (US);
William Thomas Christianson, Hendersonville, TN (US);
Benjamin Beaton, DeForest, WI (US);
Brian Burger, Madison, WI (US);
Dylan Barnes, Madison, WI (US);
Matthew Campbell, Madison, WI (US);
Genus PLC, DeForest, WI (US);
Abstract
The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties.