The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Nov. 16, 2020
Sanofi, Paris, FR;
Zhi-Yong Yang, Bridgewater, NJ (US);
Gary J. Nabel, Bridgewater, NJ (US);
Lan Wu, Bridgewater, NJ (US);
Edward Seung, Bridgewater, NJ (US);
Ronnie Wei, Needham, MA (US);
Jochen Beninga, Frankfurt am Main, DE;
Ercole Rao, Frankfurt am Main, DE;
Wulf Dirk Leuschner, Frankfurt am Main, DE;
Christian Beil, Frankfurt am Main, DE;
Christian Lange, Frankfurt am Main, DE;
Carsten Corvey, Frankfurt am Main, DE;
Sanofi, Paris, FR;
Abstract
The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.