The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 07, 2021

Filed:

Dec. 20, 2018
Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Joerg Benz, Basel, CH;

Christian Klein, Schlieren, CH;

Stefan Klostermann, Penzberg, DE;

Ekkehard Moessner, Schlieren, CH;

Johannes Sam, Schlieren, CH;

Pablo Umaña, Schlieren, CH;

Lydia Jasmin Hanisch, Schlieren, CH;

Alexander Bujotzek, Penzberg, DE;

Wei Xu, Schlieren, CH;

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01); A61K 35/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/3038 (2013.01); A61K 35/00 (2013.01); A61P 35/00 (2018.01); C07K 16/2809 (2013.01); C07K 16/2833 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/52 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present invention generally relates to antibodies that bind to HLA-A2/WT1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.


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