The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2021
Filed:
Oct. 28, 2010
Katsuto Tamai, Osaka, JP;
Yasufumi Kaneda, Osaka, JP;
Takehiko Yamazaki, Osaka, JP;
Takenao Chino, Osaka, JP;
Kotaro Saga, Osaka, JP;
Mayumi Endo, Osaka, JP;
Katsuto Tamai, Osaka, JP;
Yasufumi Kaneda, Osaka, JP;
Takehiko Yamazaki, Osaka, JP;
Takenao Chino, Osaka, JP;
Kotaro Saga, Osaka, JP;
Mayumi Endo, Osaka, JP;
STEMRIM INC., Osaka, JP;
OSAKA UNIVERSITY, Osaka, JP;
Abstract
It was revealed that the intravenous administration of HMGB-1 and S100A8 promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGB-1 was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in mice intravenously administered with HMGB-1 as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB-1 administration group. The involvement of bone marrow pluripotent stem cells in the process of bone fracture healing was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.