The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Jul. 28, 2017
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Universite Paul Sabatier Toulouse Iii, Toulouse, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Centre Hospitalier Universitaire DE Toulouse, Toulouse, FR;
Institut Claudius Regaud, Toulouse, FR;
Mary Poupot, Toulouse, FR;
Loïc Ysebaert, Toulouse, FR;
Marie Tosolini, Toulouse, FR;
Jean-Jacques Fournie, Toulouse, FR;
Pierre Brousset, Toulouse, FR;
Philippe Rochaix, Toulouse, FR;
INSERM (Institut National de la Santé et de la Recherche Médicale), Paris, FR;
Université Paul Sabatier Toulouse, Toulouse, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Centre Hospitalier Universitaire de Toulouse, Toulouse, FR;
Institut Claudius Regaud, Toulouse, FR;
Abstract
The present invention relates to antibodies targeting Tumor Associated Macrophages (TAMs) and uses thereof. The inventors investigated specific marker exposed on the surface of the macrophages associated to tumor in order to detect and target TAMs. They showed that sideroflexin 3, which is absent in normal macrophage, is expressed by tumor associated macrophages. The inventors further demonstrated that using antibody directed to sideroflexin 3, they depleted TAMs in PBMC sample obtained from LCC patient, and strongly reduced leukemic B cells number.