The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 23, 2021

Filed:

Feb. 24, 2017
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

David Lee Thomas, Lutherville, MD (US);

Ashwin Balagopal, Columbia, MD (US);

Ramy El-Diwany, Baltimore, MD (US);

Robert Siliciano, Baltimore, MD (US);

Joel Blankson, Baltimore, MD (US);

Stuart C Ray, Lutherville, MD (US);

Michel Anand Chattergoon, Baltimore, MD (US);

Justin Bailey, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/12 (2006.01); A61K 38/00 (2006.01); C12N 15/113 (2010.01); A61K 38/45 (2006.01); A61K 38/17 (2006.01); A61P 31/18 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1132 (2013.01); A61K 38/00 (2013.01); A61K 38/1709 (2013.01); A61K 38/45 (2013.01); A61P 31/18 (2018.01); C12Y 207/00 (2013.01);
Abstract

Three proteins, BCL-G (BCL2L14), CMPK2, and LAMP3, were discovered to independently restrict HIV-1 replication both in-vivo and in-vitro. Methods are described wherein subjects are given an effective amount of a pharmaceutical composition comprising a protein selected from the group consisting of BCL-G, CMPK2, LAMP3, functional parts thereof, recombinant proteins thereof, and combinations thereof, for the purpose of treating or preventing HIV.


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