The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
Mar. 29, 2017
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Peter Kwong, Washington, DC (US);
Barney Graham, Rockville, MD (US);
John Mascola, Rockville, MD (US);
Li Ou, Potomac, MD (US);
Aliaksandr Druz, Germantown, MD (US);
Man Chen, Bethesda, MD (US);
Wing-Pui Kong, Germantown, MD (US);
Ivelin Stefanov Georgiev, Nashville, TN (US);
Emily Rundlet, New York, NY (US);
Michael Gordon Joyce, Washington, DC (US);
Yaroslav Tsybovsky, Frederick, MD (US);
Paul Thomas, Washington, DC (US);
Marie Pancera, Seattle, WA (US);
Mallika Sastry, Rockville, MD (US);
Cinque Soto, Nashville, TN (US);
Joseph Van Galen, North Wales, PA (US);
Guillaume Stewart-Jones, Bethesda, MD (US);
Yongping Yang, Potomac, MD (US);
Baoshan Zhang, Bethesda, MD (US);
Ulrich Baxa, Frederick, MD (US);
Abstract
Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.