The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
May. 29, 2017
European Molecular Biology Laboratory, Heidelberg, DE;
Rastislav Horos, Heidelberg, DE;
Matthias W. Hentze, Heidelberg, DE;
Carsten Sachse, Heidelberg, DE;
European Molecular Biology Laboratory, Heidelberg, DE;
Abstract
The present invention relates to the finding that vault RNAs (vtRNA) associate with p62, an important factor of cellular autophagy. The invention provides the modulation of the binding of vtRNA to p62 as a novel strategy to influence autophagic flux in cells. Thus, the present invention provides inhibitors of vtRNA for use in the treatment of diseases associated with a pathological reduced or insufficient autophagy in cells, such as cancer and neurodegenerative disorders. Further provided are methods for screening novel therapeutic compounds modulating autophagy via the p62/vtRNA axis.