The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Oct. 03, 2017
Applicant:
Duke University, Durham, NC (US);
Inventors:
Barton F. Haynes, Durham, NC (US);
Kevin J. Wiehe, Durham, NC (US);
Mattia Bonsignori, Durham, NC (US);
Assignee:
DUKE UNIVERSITY, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01); A61K 39/21 (2006.01); C12N 7/00 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1063 (2013.01); A61K 39/21 (2013.01); C12N 7/00 (2013.01); G01N 33/56983 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); C12N 2740/16034 (2013.01);
Abstract
The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.