The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Jul. 09, 2020
The Children's Mercy Hospital, Kansas City, MO (US);
The University of Kansas, Lawrence, KS (US);
Amara Seng, Kansas City, KS (US);
Ryan Fischer, Shawnee, KS (US);
Thomas Yankee, Overland Park, KS (US);
Mary Markiewicz, Leawood, KS (US);
John Szarejko, Liberty, MO (US);
The Children's Mercy Hospital, Kansas City, MO (US);
The University of Kansas, Lawrence, KS (US);
Abstract
Cell therapy compositions comprising engineered human regulatory T cells (eTregs) characterized by ectopic overexpression of FOXP3 and Helios protein, produced via introduction of separate nucleic acid constructs respectively encoding FOXP3 and Helios (FOXP3+Helios+eTregs). Cell therapy compositions comprising mixed populations of CD4+ and CD8+ Treg cells each with ectopic overexpression of FOXP3 and Helios. Methods of making and use the same for therapies involving inflammation and/or a disorder of the immune system.