The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Jan. 17, 2019
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Alanna Schepartz Shrader, Wilton, CT (US);
Jacob S. Applebaum, New Haven, CT (US);
Jonathan R. LaRochelle, New Haven, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/42 (2017.01); A61K 47/64 (2017.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 19/00 (2006.01); C07K 14/575 (2006.01); C07K 14/465 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/00 (2013.01); A61K 47/42 (2013.01); A61K 47/645 (2017.08); A61K 47/6455 (2017.08); C07K 7/08 (2013.01); C07K 14/465 (2013.01); C07K 14/47 (2013.01); C07K 14/575 (2013.01); A61K 38/00 (2013.01); C07K 2319/10 (2013.01); C07K 2319/81 (2013.01);
Abstract
This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.