The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Oct. 25, 2017
Applicant:
The Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Timothy Alan Springer, Chestnut Hill, MA (US);
Chafen Lu, Chestnut Hill, MA (US);
Yan Qin, Andover, MA (US);
Aiping Jiang, Brookline, MA (US);
Assignee:
THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/22 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 16/28 (2013.01); C07K 16/2818 (2013.01); C07K 16/2863 (2013.01); A61K 2039/507 (2013.01); C07K 2317/20 (2013.01); C07K 2317/33 (2013.01);
Abstract
Disclosed are compositions and methods for modulating the activity of TGF-β. More particularly, compositions and methods for modulating the release of active TGF-β from an LRRC33-TGF-β prodomain-TGF-β ternary complex are provided, as are and methods of treatment based upon such modulation.