The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Nov. 28, 2018
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Brian Zeglis, New York, NY (US);
Jason Lewis, New York, NY (US);
Thomas Reiner, New York, NY (US);
Jacob Lee Houghton, New York, NY (US);
Jan-Philip Meyer, New York, NY (US);
Christian Brand, New York, NY (US);
MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US);
Abstract
Described herein are Tz/TCO-based pretargeting strategies using an Al[F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-basedF imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life,F is more readily available to produce and therefore integrated into hospital workflows.