The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2021
Filed:
May. 21, 2018
Applicant:
Northeastern University, Boston, MA (US);
Inventors:
Zhaohui Sunny Zhou, Wellesley, MA (US);
George O'Doherty, Boston, MA (US);
Shanshan Liu, Boston, MA (US);
Kevin Ryan Moulton, Brighton, MA (US);
Lincoln Ombelets, Boston, MA (US);
Amissi Sadiki, Boston, MA (US);
Assignee:
Northeastern University, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); C12P 21/06 (2006.01); C07K 1/13 (2006.01); C12N 9/10 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0002 (2013.01); C07K 1/13 (2013.01); C12N 9/1044 (2013.01); C12P 21/06 (2013.01); C12Y 203/02013 (2013.01);
Abstract
A method is provided for reversibly modifying a protein or peptide on its glutamine residue(s) by performing a reaction, such as a transglutaminase-catalyzed reaction, between the protein or peptide and an amine-containing reagent, whereby the reagent is linked through its amine function to a side chain of the glutamine residue. Subjecting the modified protein to an appropriate stimulus regenerates the protein or peptide in its original form.