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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11124605 B1

PDFFull Text
Date of Patent:
Sep. 21, 2021

Filed:

Jun. 27, 2016

Antimicrobial alpha-helical cationic polypeptides

Applicant:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Jianjun Cheng, Champaign, IL (US);

Menghua Xiong, Urbana, IL (US);

Ziyuan Song, Urbana, IL (US);

Assignee:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Attorneys:

Haukaas Fortius PLLC

Michael H. Haukaas

Primary Examiner:

Matthew P Coughlin

Assistant Examiner:

Thurman Wheeler

Int. Cl.
CPC ...
C08G 69/48 (2006.01); A61K 38/00 (2006.01); A61K 31/43 (2006.01); C08G 69/10 (2006.01); A61K 31/496 (2006.01); A61K 31/65 (2006.01); A61K 31/7036 (2006.01); A61P 31/04 (2006.01); A01N 37/46 (2006.01); A01N 43/40 (2006.01); A01N 43/42 (2006.01); A01N 43/50 (2006.01); A01N 43/52 (2006.01); A61K 31/785 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C08G 69/48 (2013.01); A01N 37/46 (2013.01); A01N 43/40 (2013.01); A01N 43/42 (2013.01); A01N 43/50 (2013.01); A01N 43/52 (2013.01); A61K 31/43 (2013.01); A61K 31/496 (2013.01); A61K 31/65 (2013.01); A61K 31/7036 (2013.01); A61K 31/785 (2013.01); A61K 38/00 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01); C08G 69/10 (2013.01); Y02A 50/30 (2018.01);
Abstract

The invention provides antimicrobial polypeptides (AMPs) with high radial amphiphilicity. Unlike typical AMPs characterized by facial amphiphilicity or biomimetic antimicrobial polymers with randomly distributed charged and hydrophobic groups, these new AMPs are homo-polypeptides with radially amphiphilic structure. They adopt a stable α-helical conformation with a hydrophobic helical core and a charged exterior shell, formed by flexible hydrophobic side chains with terminal charge group. The radially amphiphilic polypeptides offer several advantages over conventional AMPs with regard to stability against protease and simplicity of design. They also exhibit high antibacterial activity against both Gram-negative and Gram-positive bacteria and low hemolytic activity. The AMPs thus provide a general platform for treating drug-resistant bacterial infections.

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