The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Sep. 02, 2020
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Oncomyx Therapeutics, Inc., Phoenix, AZ (US);
Douglas Grant McFadden, Tempe, AZ (US);
Mohammed Masmudur Rahman, Chandler, AZ (US);
Nancy Villa, Tempe, AZ (US);
Lino Torres-Dominguez, Tempe, AZ (US);
Lina Franco Achury, Tempe, AZ (US);
Leslie Lynne Sharp, Rancho Santa Fe, CA (US);
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US);
ONCOMYX THERAPEUTICS, INC., Phoenix, AZ (US);
Abstract
Disclosed herein, in certain embodiments, are recombinant myxoma viruses (MYXVs) and nucleic acid constructs encoding the recombinant MYXVs. In some embodiments, the MYXVs are engineered to inactivate or attenuate an activity or expression level of an M153 protein. In some embodiments, the MYXVs are engineered to express one or more transgenes such as a tumor necrosis factor (TNF), interleukin-12 (IL-12), or decorin. Also disclosed herein, in certain embodiments, are methods of using the MYXVs. Some embodiments include providing a MYXV as described herein to a subject in need thereof.