The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2021
Filed:
Dec. 04, 2018
Merck Sharp & Dohme Corp., Rahway, NJ (US);
William J. Smith, Harleysville, PA (US);
Patrick McHugh, Pipersville, PA (US);
Michael Albert Winters, Doylestown, PA (US);
Julie M. Skinner, Phoenixville, PA (US);
Jian He, Blue Bell, PA (US);
Luwy Musey, Blue Bell, PA (US);
Chitrananda Abeygunawardana, Ambler, PA (US);
Yadong Adam Cui, Norristown, PA (US);
Michael J. Kosinski, Souderton, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The invention is related to multivalent immunogenic compositions comprising more than onepolysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from anserotype conjugated to a carrier protein, wherein the serotypes ofare as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection againstinfection and diseases caused by. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.