The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2021
Filed:
Jan. 25, 2017
Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;
Gregory Walter Hiller, Wakefield, MA (US);
Matthew Paul Gagnon, Medford, MA (US);
Jonathan Coffman, Union City, CA (US);
Gregory Walter Hiller, Wakefield, MA (US);
Matthew Paul Gagnon, Medford, MA (US);
Jonathan Coffman, Union City, CA (US);
Boehringer Ingelheim International GmbH, Ingelheim am Rheim, DE;
Abstract
Methods of protein production in a linked culture and production bioreactor system are provided. Such methods include a culture bioreactor (N-1 bioreactor) linked to production bioreactor (N bioreactor). More specifically, the methods include (a) culturing cells with a gene that encodes the protein of interest in a continuous perfusion culture bioreactor (N-1 bioreactor); inoculating a continuously stirred tank reactor (CSTR) production bioreactor (N bioreactor) with cells obtained from step (a); and culturing the cells in the CSTR production bioreactor under conditions that allow production of the protein of interest.