The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
May. 31, 2018
Cell Signaling Technology, Inc., Danvers, MA (US);
Victoria McGuinness Rimkunas, Reading, MA (US);
Herbert Haack, South Hamilton, MA (US);
Ting-Lei Gu, Woburn, MA (US);
Ailan Guo, Lexington, MA (US);
Anthony Paul Possemato, Worcester, MA (US);
Katherine Eleanor Crosby, Middleton, MA (US);
Meghan Ann Tucker, Salem, MA (US);
Cynthia Beaudet, Beverly, MA (US);
CELL SIGNALING TECHNOLOGY, INC., Danvers, MA (US);
Abstract
The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer).