The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 24, 2021

Filed:

Jun. 23, 2017
Applicants:

Kyowa Hakko Bio Co., Ltd., Tokyo, JP;

Otsuka Pharmaceutical Factory, Inc., Naruto, JP;

Inventors:

Tomoya Yokoi, Tokyo, JP;

Hiroshi Nagano, Tokyo, JP;

Takayuki Shimizu, Naruto, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 227/42 (2006.01); C07C 229/26 (2006.01); C07C 51/41 (2006.01); C07C 59/01 (2006.01); C07C 51/43 (2006.01); C07C 277/06 (2006.01); C07C 279/14 (2006.01);
U.S. Cl.
CPC ...
C07C 227/42 (2013.01); C07C 51/41 (2013.01); C07C 51/43 (2013.01); C07C 59/01 (2013.01); C07C 229/26 (2013.01); C07C 277/06 (2013.01); C07C 279/14 (2013.01); C07B 2200/13 (2013.01);
Abstract

An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.


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