The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Feb. 20, 2018
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Jian He, Blue Bell, PA (US);
John E. MacNair, Lansdale, PA (US);
William J. Smith, Harleysville, PA (US);
Michael A. Winters, Doylestown, PA (US);
Joseph G. Joyce, Lansdale, PA (US);
Chitrananda Abeygunawardana, Ambler, PA (US);
Luwy Musey, Blue Bell, PA (US);
Hari Pujar, Berwyn, PA (US);
Julie M. Skinner, Phoenixville, PA (US);
Emily Wen, Harleysville, PA (US);
Patrick McHugh, Pipersville, PA (US);
John Michael Williams, Hillsborough, NJ (US);
Catherine Lancaster, Southhampton, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides frombacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.