The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11078240 B1

PDF
Full Text
Expired
Date of Patent:
Aug. 03, 2021

Filed:

Nov. 10, 2017
Applicant:

Fraunhofer Usa Inc., Newark, DE (US);

Inventors:

Stephen Tottey, Swarthmore, PA (US);

Konstantin Musiychuk, Wilmington, DE (US);

Assignee:

Fraunhofer USA Inc., Newark, DE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/82 (2006.01); C07K 14/415 (2006.01); C12N 9/22 (2006.01); C12N 15/90 (2006.01); A61K 39/00 (2006.01); C07K 14/005 (2006.01); A61K 39/015 (2006.01); A61K 39/12 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/015 (2013.01); A61K 39/12 (2013.01); C12N 15/111 (2013.01); A61K 2039/5258 (2013.01); C07K 2319/00 (2013.01); C12N 2760/16134 (2013.01);
Abstract

A fusion protein comprising a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may form a virus like particle (VLP). Where the fusion protein further comprises a target protein, the target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.


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