The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Sep. 14, 2015
Applicant:
Salk Institute for Biological Studies, La Jolla, CA (US);
Inventors:
Clodagh O'Shea, San Diego, CA (US);
Shigeki Miyake-Stoner, La Jolla, CA (US);
Assignee:
Salk Institute for Biological Studies, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/761 (2015.01); C12N 15/861 (2006.01); C12N 15/34 (2006.01); A61K 48/00 (2006.01); C12N 15/09 (2006.01); C12N 15/86 (2006.01); A61K 35/768 (2015.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/761 (2013.01); A61K 35/768 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2710/10021 (2013.01); C12N 2710/10032 (2013.01); C12N 2710/10043 (2013.01);
Abstract
An adenovirus comprising an E1A polypeptide comprising one or more modifications and comprising an E4orf6/7 polypeptide comprising one or more modifications is described. Compositions and kits comprising the modified adenoviruses are also described. Further described is a method of treating a proliferative disorder in a subject comprising administering to the subject an adenovirus comprising the E1A polypeptide comprising one or more modifications and comprising the E4orf6/7 polypeptide comprising one or more modifications.