The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Nov. 30, 2011
Applicants:
Junichi Nezu, Shizuoka, JP;
Takahiro Ishiguro, Kanagawa, JP;
Atsushi Narita, Shizuoka, JP;
Akihisa Sakamoto, Shizuoka, JP;
Yumiko Kawai, Kanagawa, JP;
Tomoyuki Igawa, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Inventors:
Junichi Nezu, Shizuoka, JP;
Takahiro Ishiguro, Kanagawa, JP;
Atsushi Narita, Shizuoka, JP;
Akihisa Sakamoto, Shizuoka, JP;
Yumiko Kawai, Kanagawa, JP;
Tomoyuki Igawa, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Assignee:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/46 (2013.01); C07K 16/2809 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C07K 16/303 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/60 (2013.01); C07K 2317/622 (2013.01); C07K 2317/64 (2013.01); C07K 2317/71 (2013.01); C07K 2317/73 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.