The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Sep. 21, 2017
Applicant:
Stephen H. Thorne, Pittsburgh, PA (US);
Inventor:
Stephen H. Thorne, Pittsburgh, PA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 45/06 (2006.01); A61K 31/7088 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 31/7088 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/4702 (2013.01); C12N 2710/24132 (2013.01); Y02A 50/30 (2018.01);
Abstract
Provided herein are oncolytic vaccinia viruses which have been modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein. Such vaccinia viruses modified to contain nucleic acid encoding variant HMGB1 and that express a variant HMGB1 or a fragment thereof can achieve a synergistic effect in combination with chemotherapy. Methods of using oncolytic vaccinia viruses modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein, in the treatment of various cancers, are also provided.