The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Mar. 11, 2015
University of South Carolina, Columbia, SC (US);
Michael Matthews, Columbia, SC (US);
Dominic M. Casali, Columbia, SC (US);
University of South Carolina, Columbia, SC (US);
Abstract
Decellularization methods for tissue are provided. The method can include: exposing a tissue to a water-saturated, supercritical CO. The method can further comprise, prior to exposing the tissue to the water-saturated, supercritical CO, saturating a stream of supercritical CO. The tissue can be exposed to the water-saturated, supercritical COat a treatment temperature of about 35° C. to about 40° C. (e.g., about 37° C.). In one embodiment, the water-saturated, supercritical COis completely saturated with water at the treatment temperature. The tissue can be exposed to the water-saturated, supercritical COat a constant flow rate, such as less than 3 mL/min (e.g., about 0.5 mL/min to about 2.5 mL/min).