The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Dec. 01, 2017
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Georg Jaeschke, Basel, CH;
Lothar Lindemann, Basel, CH;
Antonio Ricci, Biel-Benken, CH;
Eric Vieira, Frenkendorf, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4184 (2006.01); A61K 31/4166 (2006.01); A61K 31/4439 (2006.01); C07D 403/04 (2006.01); C07D 235/02 (2006.01); C07C 11/22 (2006.01); C07D 401/04 (2006.01); A61K 31/44 (2006.01); C07D 213/81 (2006.01);
U.S. Cl.
CPC ...
C07C 11/22 (2013.01); A61K 31/4166 (2013.01); A61K 31/4184 (2013.01); A61K 31/44 (2013.01); C07D 213/81 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); A61K 2300/00 (2013.01);
Abstract
The present invention relates to ethynyl derivatives of formula I with variables as defined herein, or to a pharmaceutically acceptable acid addition salt thereof. Compounds of formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of, e.g., anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).