The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2021
Filed:
Apr. 29, 2016
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Gavril Pasternak, New York, NY (US);
Susruta Majumdar, Stamford, CT (US);
Rashad Karimov, Berkeley, CA (US);
Andras Varadi, New York, NY (US);
Assignee:
Memorial Sloan-Kettering Cancer Center, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/438 (2006.01); C07D 471/20 (2006.01); C07D 471/14 (2006.01); A61P 25/18 (2006.01); A61P 25/04 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/14 (2013.01); A61K 31/438 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01); A61P 25/04 (2018.01); A61P 25/18 (2018.01); A61P 29/00 (2018.01); C07D 471/20 (2013.01);
Abstract
Described herein are compounds of Formulae (I')-(II′), compounds of Formulae (I)-(II) and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful for modulating opioid receptor activity. The provided compounds may have both agonistic and antagonistic effect on one or more opioid receptors. Methods of using the compounds for treating or managing pain are also described.