The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Jan. 06, 2017
Novartis Ag, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Jennifer Brogdon, Cambridge, MA (US);
Saar Gill, Philadelphia, PA (US);
Carl H. June, Merion Station, PA (US);
Michael D. Kalos, New York, NY (US);
Andreas Loew, Cambridge, MA (US);
John Scholler, Narberth, PA (US);
Novartis AG, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.