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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11026958 B1

PDFFull Text
Date of Patent:
Jun. 08, 2021

Filed:

Oct. 30, 2017

Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Brendan M. Crowley, Collegeville, PA (US);

Ian M. Bell, Harleysville, PA (US);

Andrew John Harvey, Paddington, AU;

Brian T. Campbell, Bensalem, PA (US);

Thomas J. Greshock, Collegeville, PA (US);

Vanessa L. Rada, Hatfield, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Patricia A. Shatynski

John C. Todaro

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
A61K 31/695 (2006.01); A61K 31/198 (2006.01); C07D 213/34 (2006.01); C07D 413/04 (2006.01); C07D 239/26 (2006.01); C07D 401/04 (2006.01); C07D 271/06 (2006.01); C07D 233/64 (2006.01); C07D 249/08 (2006.01); A61K 31/4418 (2006.01); A61K 31/5377 (2006.01); A61K 31/505 (2006.01); A61K 31/4439 (2006.01); A61K 31/4245 (2006.01); A61K 31/506 (2006.01); A61K 31/50 (2006.01); A61K 31/4965 (2006.01); C07D 237/08 (2006.01); C07D 241/12 (2006.01); C07F 7/08 (2006.01); A61K 31/4196 (2006.01); A61K 31/4164 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/695 (2013.01); A61K 31/198 (2013.01); A61K 31/4164 (2013.01); A61K 31/4196 (2013.01); A61K 31/4245 (2013.01); A61K 31/4418 (2013.01); A61K 31/4439 (2013.01); A61K 31/4965 (2013.01); A61K 31/50 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 213/34 (2013.01); C07D 233/64 (2013.01); C07D 237/08 (2013.01); C07D 239/26 (2013.01); C07D 241/12 (2013.01); C07D 249/08 (2013.01); C07D 271/06 (2013.01); C07D 401/04 (2013.01); C07D 413/04 (2013.01); C07F 7/0812 (2013.01);
Abstract

The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

Find Patent Forward Citations

Crowley, Brendan. (2021). Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors (U.S. Patent No. 11026958). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11026958

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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