The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2021
Filed:
Aug. 19, 2016
Applicant:
Shanghai Institute of Biological Products Co., Ltd., Shanghai, CN;
Inventors:
Assignee:
SHANGHAI INSTITUTE OF BIOLOGICAL PRODUCTS CO., LTD., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/06 (2006.01); A61K 47/60 (2017.01); C12Q 1/62 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0048 (2013.01); A61K 47/60 (2017.08); C12Q 1/62 (2013.01); C12Y 107/03003 (2013.01); A61K 38/00 (2013.01);
Abstract
A mutant-type uricase, PEG modified mutant-type uricase, and application thereof. The mutant-type uricase has a cysteine residue introduced by recombination, the cysteine residue is located at an inactive region of the uricase, and one or more PEGs are coupled to the mutant-type uricase. The resulting PEGylated mutant-type uricase has characteristics of a half-life extension, product uniformity, and stable enzyme activity. Therefore, the present invention has a wide future application range.