The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2021
Filed:
May. 01, 2018
Applicant:
Agenus Inc., Lexington, MA (US);
Inventors:
Dhan Sidhartha Chand, Woburn, MA (US);
Nicholas Stuart Wilson, San Carlos, CA (US);
Dennis John Underwood, Boston, MA (US);
Benjamin Maxime Morin, Somerville, MA (US);
Assignee:
AGENUS INC., Lexington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61P 35/04 (2006.01); C07K 16/30 (2006.01); G01N 33/50 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2818 (2013.01); A61K 39/395 (2013.01); A61P 35/04 (2018.01); C07K 16/28 (2013.01); C07K 16/2875 (2013.01); C07K 16/2878 (2013.01); C07K 16/30 (2013.01); G01N 33/505 (2013.01); A61K 2039/57 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/52 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/73 (2013.01); C07K 2317/734 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01);
Abstract
The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.