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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11020398 B1

PDFFull Text
Date of Patent:
Jun. 01, 2021

Filed:

Aug. 23, 2017

Amino-pyrrolopyrimidinone compounds and methods of use thereof

Applicant:

Arqule, Inc., Burlington, MA (US);

Inventors:

Craig Bates, Pelham, NH (US);

Sudharshan Eathiraj, Shrewsbury, MA (US);

Hiroaki Inagaki, Tokyo, JP;

Jean-Marc Lapierre, Pelham, NH (US);

Takayuki Momose, Tokyo, JP;

Kiyoshi Nakayama, Tokyo, JP;

Takashi Odagiri, Tokyo, JP;

Masahiro Ota, Tokyo, JP;

Yusuke Ota, Tokyo, JP;

Yoshihiro Shibata, Tokyo, JP;

Manish Tandon, Framingham, MA (US);

Tomoyuki Tsunemi, Tokyo, JP;

Assignee:

ArQule, Inc., Burlington, MA (US);

Attorneys:

Cooley LLP

Matthew Pavao

Chen Chen

Primary Examiner:

Susanna Moore

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/4188 (2006.01); C12N 9/12 (2006.01); A61K 31/03 (2006.01); A61K 31/341 (2006.01); A61P 9/00 (2006.01); A61P 7/04 (2006.01); A61P 43/00 (2006.01); A61P 37/08 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01); A61P 25/00 (2006.01); A61P 19/02 (2006.01); A61P 17/00 (2006.01); A61P 11/06 (2006.01); A61P 1/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/4188 (2013.01); C07D 487/04 (2013.01); C12N 9/12 (2013.01); A61K 31/03 (2013.01); A61K 31/341 (2013.01);
Abstract

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

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